Opposed Steric Constraints in Human DNA Polymerase β and E. coli DNA Polymerase I
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چکیده
منابع مشابه
Opposed Steric Constraints in Human DNA Polymerase and E. coli DNA Polymerase I
DNA polymerase selectivity is crucial for the survival of any living species, yet varies significantly among different DNA polymerases. Errors within DNA polymerase-catalyzed DNA synthesis result from the insertion of noncanonical nucleotides and extension of misaligned DNA substrates. The substrate binding characteristics among DNA polymerases are believed to vary in properties such as shape a...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2008
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja8028284